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Literature summary extracted from

  • Claus, T.H.; Lowe, D.B.; Liang, Y.; Salhanick, A.I.; Lubeski, C.K.; Yang, L.; Lemoine, L.; Zhu, J.; Clairmont, K.B.
    Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose (2005), J. Pharmacol. Exp. Ther., 315, 1396-1402.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.79 medicine inhibition of hormone-sensitive lipase may improve insulin sensitivity and blood glucose handling in type 2 diabetes. The utility of enzyme inhibition in diabetes treatment will depend on the presence or absence of adverse effects of inhibition in tissues beyond the adipocyte Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.79 additional information Homo sapiens the enzyme is involved in the hormone regulated release of fatty acids and glycerol from adipocyte lipid stores ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.79 Homo sapiens
-
 recombinant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.79 additional information the enzyme is involved in the hormone regulated release of fatty acids and glycerol from adipocyte lipid stores Homo sapiens ?
-
 ?